Neutrophil products inhibiting cell proliferation [letter]
نویسندگان
چکیده
منابع مشابه
Neutrophil products that inhibit cell proliferation: relation to granulocytic "chalone".
Various investigators have proposed the existence of a “chalone” or product of mature granulocytes which inhibits the replication of granulocytic progenitors in a tissue-specific, species-nonspecific regulatory system. We tested this system utilizing purified populations of human leukocytes and a variety of proliferating target cell populations. Granulocyte-conditioned medium potently inhibited...
متن کاملShikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation
The M2 isoform of pyruvate kinase M2 (PKM2) has been shown to be up-regulated in human skin cancers. To test whether PKM2 may be a target for chemoprevention, shikonin, a natural product from the root of Lithospermum erythrorhizon and a specific inhibitor of PKM2, was used in a chemically-induced mouse skin carcinogenesis study. The results revealed that shikonin treatment suppressed skin tumor...
متن کاملFactors inhibiting cell proliferation in rat liver cytoplasm.
Two factors from normal rat liver cytoplasm inhibited the proliferation of cultured L-929 fibroblasts. One was arginase, the other was a small molecular weight inhibitor stable to trypsin and heat treatment. The small molecular weight inhibitor inhibited the protein and DNA synthesis of L-cells. Inhibition of DNA synthesis was thought to be secondary to the inhibition of protein synthesis.
متن کاملmiR-141 promotes colon cancer cell proliferation by inhibiting MAP2K4
MicroRNAs (miRNAs or miRs) can function as tumor-suppressor or oncogenic genes. Upregulation of miRNA-141 has been frequently observed in colorectal cancer (CRC) samples. The experimentally observed targets of miR-141 include the tumor-suppressor gene mitogen-activated protein kinase kinase 4 (MAP2K4). The aim of the present study was to investigate the role of miR-141 in the proliferation of c...
متن کاملNeutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function.
Myeloperoxidase (MPO) is important in intracellular microbial killing by neutrophils but extracellularly causes tissue damage. Its role in adaptive immunity and T-cell-mediated diseases is poorly understood. Here, T-cell responses in lymph nodes (LNs) were enhanced by MPO deletion or in vivo inhibition, causing enhanced skin delayed-type hypersensitivity and antigen (Ag)-induced arthritis. Resp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1978
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v52.3.640.bloodjournal523640